Abstract Search

ea0035p337 | Developmental Endocrinology | ECE2014

Crystal structure of Drosophila imaginal morphogenesis protein-Late 2 (IMP-L2) in free form and bound to Drosophila insulin-like peptide 5 (DILP5) and human Insulin-like growth factor-I (hIGF1).

Kulahin Nikolaj , Watson Christopher J. , Sajid Waseem , Schluckebier Gerd , Kristensen Claus , Andersen Asser Sloth , Kristensen Ole , Norrman Matthias , Meyts Pierre De , Brzozowski Andrzej Marek

The insulin signalling system including the insulin receptor tyrosine kinase (IRTK) is evolutionarily ancient. The Drosophila Melanogaster genome contains seven genes for insulin-like peptides (ILPs) that are expressed in neurosecretory cells in a highly tissue- and stage-specific pattern, DILP17. There is however only one IRTK (dIR). This system is important in the regulation of metabolism, growth, reproduction and lifespan. We reported in 2011 the crystal stru...

1 shares

Endocrine Abstracts

Crystal structure of Drosophila imaginal morphogenesis protein-Late 2 (IMP-L2) in free form and bound to Drosophila insulin-like peptide 5 (DILP5) and human Insulin-like growth factor-I (hIGF1).

BiosciAbstracts